Value of 25 mcg Cortrosyn Stimulation Test

Completed · Not applicable

Conditions studied: Adrenal Insufficiency

In brief

The diagnosis of secondary AI is vital to prevent catastrophic events in patients. An optimal test should have a very low margin of error with high sensitivity and specificity, be easy and safe to administer, and have distinct cut off values. Both 1 ug and 250 ug doses have their limitations. Based on our experience over the past six years, we hypothesize that 25 ug ACTH stimulation test may eliminate some of the shortcomings of the LDST (1 ug) and SDST (250 ug). This is supported by our preliminary data and the study by Oelkers et al, which looked at ACTH levels following various doses of cortrosyn injections. Therefore we propose a head to head comparison of 25 ug, 250 ug and 1 ug dose using ITT as gold standard.

Key facts

Study ID

NCT01428336

Run by

The Cleveland Clinic

People needed

22

Starts

2011-09-01

Expected to finish

2015-01-01

Last updated by the study team

2017-07-25

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• hypothalamic-pituitary-adrenal disorders

You may not qualify if…

• under 18 or older than 65 years of age

Where it is running

• Cleveland Clinic Department of Endocrinology — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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