Id-KLH Vaccine + T Cells in Subjects With Myeloma Undergoing Transplant

Completed · Phase 2

Conditions studied: Multiple Myeloma

In brief

This study will enroll myeloma subjects undergoing autotransplantation. The primary objective of this study is to evaluate whether infusions of Id-KLH primed CD3/CD28 activated autologous lymphocytes mediate a more intense Id-specific immunity than non Id-KLH primed CD3/CD28 activated autologous lymphocytes. There will be 2 arms in the study, one receiving a DLI with non Id-KLH vaccine and one receiving aDLI with Id-KLH vaccine.

Key facts

Study ID

NCT01426828

Run by

University of Pennsylvania

People needed

40

Starts

2011-08-01

Expected to finish

2017-12-01

Last updated by the study team

2020-12-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• SCREEN #1 (Visit 1) Step 1:
• Diagnosis of symptomatic multiple myeloma.
• Less than 10 months after initiation of systemic therapy.
• One or two lines of induction therapy with commonly used regimens.
• Age greater than or equal to 18 years to less than or equal to 70 years at the time of enrollment.
• IgG paraprotein (not of IgG3 subtype) with a paraprotein peak (M-spike) of ≥0.2 g/dL. Alternatively subjects who have previously stored purified Id-specific protein on other clinical or laboratory protocols.
• Echocardiogram or MUGA with an ejection fraction of 45% or more and no uncompensated congestive heart failure or uncontrolled arrhythmias.
• Adequate pulmonary function as defined by FEV1, FVC and actual or corrected DLCO of 50% or greater of the predicted value for age, sex and size.
• Adequate renal function as defined by creatinine of 2.0 mg/dl or less or a creatinine clearance of 40cc/min or more.
• Adequate hepatic function as defined by a total bilirubin of 2.0 mg/dl or less and AST and ALT less than 2 times upper limit of normal.
• Ability to sign written informed consent.
• Karnofsky performance status of at least 80% or more.
• Negative serum Beta HCG test in women of child bearing potential and agree to use a medically acceptable form of birth control while on the study drugs.
• Exclusion:
• Subjects with melphalan-based induction
• Active uncontrolled infection
• HIV+ or active hepatitis B or C as defined by positive viral load or serology.
• Pre-existing autoimmune diseases, with exception of Hashimoto's thyroiditis.
• Concurrent use of systemic steroids at the time of cell infusion or cell collection, or a condition, in the treating physician's opinion, that is likely to require steroid therapy during Tcell collection or after infusion. Steroids for disease treatment at times other than cell collection or at the time of infusion are permitted. Use of inhaled steroids is permitted as well.
• Prior autologous or allogeneic transplant.
• For this study, there will be no exceptions to eligibility granted.
• 2 PRE-VACCINE #1 ASSESSMENT (Visit 3) Step 2
• Subjects must meet the following criteria to proceed with vaccination:
• Less than 9 months from randomization.
• Adequate renal function as defined by creatinine of 2.0 mg/dl or less or a creatinine clearance of 40cc/min or more.

Where it is running

• Abramson Cancer Center of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Texas, MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.