Autoregulation Assessment During Liver Transplantation

Completed

Conditions studied: Liver Failure, Liver Transplantation, Encephalopathy

In brief

Patients with liver failure undergoing liver transplantation often have clinical or sub-clinical encephalopathy that may lead to increased intracranial pressure. The latter may lead to abnormal regulation of blood flow to the brain (cerebral autoregulation) complicating patient management during and after general anesthesia. The current methods for monitoring for elevated intracranial pressure are invasive and, thus, limited to severe encephalopathy. In this study the investigators will evaluate the potential utility of monitoring cerebral blood flow (CBF) autoregulation non-invasively using near infra-red spectroscopy in patients undergoing liver transplantation.

Key facts

Study ID

NCT01425385

Run by

Johns Hopkins University

People needed

10

Starts

2011-09-01

Expected to finish

2012-09-01

Last updated by the study team

2017-08-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years old and undergoing liver transplantation.

You may not qualify if…

• Clinical instability as judged by the attending physicians whereby autoregulation monitoring may interfere with clinical care.
• Women of child bearing potential require a negative urine human chorionic gonadotropin (HCG) test to be enrolled.

Where it is running

• The Johns Hopkins Hospital — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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