Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina

Completed · Phase 4 · Has a placebo group

Conditions studied: Angina Pectoris, Coronary Artery Disease, Type 2 Diabetes Mellitus

In brief

This study will evaluate the effect of ranolazine compared to placebo on the average weekly angina frequency in subjects with chronic stable angina and coronary artery disease (CAD) who have a history of type 2 diabetes mellitus (T2DM), and whether ranolazine can reduce the frequency of angina (chest pain) attacks, compared to a placebo. Subjects will be asked to record their daily angina episodes in a diary at the end of each study day. Ranolazine is approved for the treatment of chronic angina, and is not approved for the treatment of T2DM.

Key facts

Study ID

NCT01425359

Run by

Gilead Sciences

People needed

949

Starts

2011-09-01

Expected to finish

2012-10-01

Last updated by the study team

2014-11-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Written informed consent
• Males and females aged at least 18 years
• At least a 3-month history of chronic stable angina triggered by physical effort and relieved by rest and/or sublingual nitroglycerin
• CAD documented by one or more of the following:
• Angiographic evidence of ≥ 50% stenosis of one or more major coronary arteries
• History of myocardial infarction (MI) documented by positive myocardial muscle creatine kinase (CK-MB) enzymes, troponins, or electrocardiogram (ECG) changes
• Cardiac imaging study or exercise test diagnostic for CAD
• Treatment with up to 2 antianginal therapies at a stable dose for at least 2 weeks prior to the Qualifying Period.
• Documented history of T2DM
• Willing to maintain stable tobacco usage habits throughout the study
• Willing to maintain stable activity levels throughout the study
• Females of childbearing potential must agree to utilize highly effective contraception methods from Screening throughout the duration of study treatment and for 14 days following the last dose of study drug.

You may not qualify if…

• New York Heart Association (NYHA) Class III and IV
• Acute coronary syndrome in the prior 2 months or planned coronary revascularization during the study period
• Stroke or transient ischemic attack within 6 months prior to Screening
• QTc > 500 milliseconds
• Uncontrolled hypertension (seated systolic blood pressure > 180 mmHg or diastolic blood pressure > 110 mmHg)
• Systolic blood pressure < 100 mmHg
• Clinically significant hepatic impairment
• Prior treatment with ranolazine, or known hypersensitivity or intolerance to ranolazine
• Females who are breastfeeding
• Positive serum pregnancy test
• Participation in another investigational drug or device study within 1 month prior to Screening
• Current treatment with trimetazidine, ivabradine, or nicorandil. Subjects will need to discontinue these medications 2 weeks prior to the Qualifying Period.
• Current treatment with potent inhibitors of cytochrome (CYP)3A (eg, ketoconazole, itraconazole, clarithromycin, nefazodone, nelfinavir, ritonavir, indinavir, and saquinavir)
• Current treatment with CYP3A and P glycoprotein (Pgp) inducers (eg, rifampicin/rifampin, carbamazepine, and St. John's wort [Hypericum perforatum])
• Current treatment with CYP3A4 substrates with a narrow therapeutic range (eg, cyclosporine, tacrolimus, and sirolimus)
• Subjects taking simvastatin who cannot reduce the dose to 20 mg once daily or who cannot switch to another statin
• Current treatment with Class I or III antiarrhythmic medications
• History of illicit drug use or alcohol abuse within 1 year of Screening
• Any other conditions that, in the opinion of the investigator, are likely to prevent compliance with the study protocol or pose a safety concern if the subject participates in the study

Where it is running

• Merced Heart Associates — Merced, California, United States
• Spectrum Clinical Research Institute, Inc — Moreno Valley, California, United States
• Sacramento Heart and Vascular Research Center — Sacramento, California, United States
• South Florida Research Solutions, LLC — Hollywood, Florida, United States
• Baptist Heart Specialist — Jacksonville, Florida, United States
• Clinical Research of Central Florida — Winter Haven, Florida, United States
• Masters of Clinical Research, Inc. — Augusta, Georgia, United States
• Columbus Cardiology Associates — Columbus, Georgia, United States
• Central Cardiology Associates — Elizabethtown, Kentucky, United States
• Research Integrity, LLC — Owensboro, Kentucky, United States
• Alexandria Cardiology Clinic — Alexandria, Louisiana, United States
• Clinical Trials Management, LLC — Mandeville, Louisiana, United States
• Endeavor Medical Research, PLC — Alpena, Michigan, United States
• Minneapolis Heart Institute Foundation — Minneapolis, Minnesota, United States
• Cross Country Cardiology — Edgewater, New Jersey, United States
• Kore CV Research — Jackson, Tennessee, United States
• Wellmont Cardiovascular Associates Heart Institute — Johnson City, Tennessee, United States
• Med-Tech Research — Houston, Texas, United States
• Humble Cardiology Associates — Humble, Texas, United States
• State Institution "Gomel regional clinical hospital" — Homyel, Belarus
• State Inst Rep Scientific and Practical center — Minsk, Belarus
• Diagnostic Consultative Center, Ascendent Cardiological Out-Patient Office — Sofia, Bulgaria
• MHAT "Tsar Boris III" — Sofia, Bulgaria
• National Cardiology Center, Cardiology Clinic - III — Sofia, Bulgaria
• Cardiology and Medicine Clinic — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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