Noninvasive Predictors of Transplant Vasculopathy

Withdrawn before enrolling

Conditions studied: Cardiac Allograft Vasculopathy

In brief

Post transplant vasculopathy is a major negative outcome in heart transplantation. Current methods of detection are highly invasive and pose a risk to transplant recipients. Noninvasive markers of endothelial function can be used to detect transplant vasculopathy. Endothelial biomarkers such as: endothelial nitric oxide synthase, vascular cellular adhesion molecules, intracellular adhesion molecules, endothelin-1, thromboplastin, circulating endothelial cells, uric acid, and C-reactive play a role in the pathophysiologic mechanism of vasculopathy. Therefore, the investigators would like to assess the association between various endothelial biomarkers and the presence or absence of transplant vasculopathy.

Key facts

Study ID

NCT01424917

Run by

University of Minnesota

People needed

0

Starts

2008-03-01

Expected to finish

2013-12-01

Last updated by the study team

2017-01-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provide informed consent
• Age 18 years and greater
• Cardiac transplant recipients who have been transplanted for more than one year

You may not qualify if…

• Chronic kidney disease stage 4 defined as GFR <30
• Acute Rejection grade 3A or greater
• Active Infection
• Re-transplant
• Multiorgan Transplant

Where it is running

• Cardiology Division, University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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