Diet and Systemic Inflammation
Completed · Not applicable
Conditions studied: Low-grade Chronic Inflammation, Intestinal Permeability, Type 2 Diabetes Mellitus, Cardiovascular Disease, Obesity
In brief
People with chronic low-grade inflammation have a higher risk for certain diseases such as cardiovascular disease or type 2 diabetes. While it is known that obese people are more likely to show signs of low-grade inflammation than lean individuals, it is unclear what causes this inflammation. In the proposed study, the investigators will examine whether the sugar fructose, when consumed in a sweetened beverage, triggers low-grade inflammation in healthy men and women compared with other caloric sweeteners.
Key facts
- Study ID
- NCT01424306
- Run by
- Fred Hutchinson Cancer Center
- People needed
- 25
- Starts
- 2011-10-01
- Expected to finish
- 2014-04-01
- Last updated by the study team
- 2017-08-14
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age: 18-65 years;
- BMI 20-40 kg/m2;
- Weight stable to within 10 pounds for 6 months prior to entering the study, and at their lifetime maximum weight (or within 30 pounds of it; excluding pregnancy);
- Ability to be admitted for \~30 minutes on three occasions, and \~6 hours on three occasions to the FHCRC Prevention Center;
- Ability to provide informed written consent;
- Willingness to consume only food and beverages provided by the Human Nutrition Laboratory of the FHCRC Prevention Center for three periods of 8 days each.
You may not qualify if…
- Presence or history of chronic inflammatory, autoimmune or metabolic diseases;
- Presence of phenylketonuria, hereditary fructose intolerance, fructose malabsorption, or malabsorption syndromes;
- Abuse of alcohol (>2 drinks per day), smoking, or use of recreational drugs;
- Current or recent (within three months) intake of medications likely to interfere with study endpoints (insulin, antidiabetics, β-blockers, anabolic steroids, glucocorticosteroids, daily high-dose non-steroidal anti-inflammatory drugs, warfarin, antibiotics, probiotics);
- Presence of anemia, recent (within 2 months) history of anemia;
- Anyone not willing or able to eat the provided food;
- Current or recent (within 12 months) pregnancy or breastfeeding.
Where it is running
- Fred Hutchinson Cancer Research Center — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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