Effect of Vitamin D Supplementation on In-vitro Fertilization (IVF) Outcomes

Stopped early

Conditions studied: Infertility, Vitamin D Deficiency

In brief

Historically, vitamin D has been considered to play a role solely in bone and calcium metabolism. Numerous studies have suggested a link between vitamin D deficiency and adverse health outcomes such as malignancy, cardiovascular disease, immune functioning, and glucose metabolism. In the obstetrics literature, vitamin D deficiency has been linked to preeclampsia, gestational diabetes, and increased rate of cesarean section rate. Recent data from retrospective chart reviews have demonstrated a possible role of vitamin D in implantation and clinical pregnancy rates in patients undergoing in-vitro fertilization. Patients found to be deficient in vitamin D were found to have significantly lower clinical pregnancy rates when compared to patients who were replete in vitamin D levels. Currently, there are no prospective clinical trials investigating the effects of vitamin D supplementation on IVF outcomes such as clinical pregnancy rate and implantation rates. The investigators hypothesize that the vitamin D supplementation in patients found to be either deficient or insufficient in vitamin D will lead to improved pregnancy rates in infertility patients undergoing in-vitro fertilization.

Key facts

Study ID

NCT01419743

Run by

Northwestern University

People needed

102

Starts

2011-08-01

Expected to finish

2014-01-01

Last updated by the study team

2014-02-19

Who can join

Age: 18 and older, up to 38. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Infertile women aged ≤ 38 years undergoing fresh invitro fertilization cycles

You may not qualify if…

• Infertile women aged > 38 undergoing fresh invitro fertilization cycles
• Patients undergoing frozen embryo transfers
• Patients undergoing donor-egg cycles
• Patients who have a contraindication to receiving Vitamin D (e.g. patients with history of primary hyperparathyroidism, sarcoidosis, tuberculosis, kidney disease, or lymphoma)

Where it is running

• Northwestern Memorial Faculty Foundation — Chicago, Illinois, United States
• Northwestern Memorial Hospital — Chicago, Illinois, United States
• Northwestern University Feinberg School of Medicine — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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