Effect of Ischemic Strokes on Recovery From Intracerebral Hemorrhages
Completed
Conditions studied: Hemorrhage; Intracerebral, Nontraumatic, Ischemic Strokes, Diffusion Weighted Imaging Lesions
In brief
Intracerebral hemorrhage (ICH) occurs when small arteries in the brain rupture due to weakening by age, high blood pressure, and/or elevated cholesterol. In addition to artery rupture, recent data suggests that patients with ICH are also at risk for developing occlusion of arteries during the acute phase, called ischemic strokes. Data suggests these ischemic strokes can negatively impact patient outcomes. Diffusion weighted imaging (DWI) is a sequence on Magnetic Resonance Imaging (MRI) that is a sensitive marker for ischemic strokes in the brain. In this proposal, our primary aim is examine prospectively the effect DWI abnormalities have on functional outcomes in patients with ICH. Our hypothesis is that the DWI abnormalities found on MRI of the brain lead to worse functional outcomes in patients with ICH
Key facts
- Study ID
- NCT01417117
- Run by
- Rush University Medical Center
- People needed
- 130
- Starts
- 2011-09-01
- Expected to finish
- 2017-06-01
- Last updated by the study team
- 2017-10-20
Who can join
Age: 19 and older, up to 79. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients > 18 years and < 80 years
- Spontaneous intracerebral hemorrhage documented by CT scan
- Less than 24 hours from time last seen normal to first medical evaluation
- No prior clinical history of stroke (i.e. subarachnoid hemorrhage, ICH, or ischemic strokes)
You may not qualify if…
- Pregnancy
- History of cancer
- Pre-admission mRS > 2
- Glasgow Coma Scale less than 5
- ICH secondary to aneurysm, vascular malformation, mycotic aneurysm, primary or metastatic tumor, trauma, warfarin-related ICH, acute-fibrinolytic associated ICH, or coagulopathy
- Associated epidural or subdural hematoma
- Surgical intervention < 48 hours from admission
- Hemodynamic instability (need for vasopressor therapy)
- Acute hypoxemic or hypercapnic respiratory failure
- History of deep venous thrombosis
- Contraindications to MRI based upon institutional safety checklist
Where it is running
- Rush University Medical Center — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.