Rituximab, Bendamustine Hydrochloride, and Bortezomib Followed by Rituximab and Lenalidomide in Treating Older Patients With Previously Untreated Mantle Cell Lymphoma
Running, not enrolling · Phase 2
Conditions studied: Lymphoma, Mantle Cell Lymphoma
In brief
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and help kill them or carry cancer-killing substances to them. Others interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as bendamustine hydrochloride, also work in different ways to kill cancer cells or stop them from dividing. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Lenalidomide may stop the growth of mantle cell lymphoma by blocking blood flow to the cancer. It is not yet known whether giving rituximab together with bendamustine and bortezomib is more effective than rituximab and bendamustine, followed by rituximab alone or with lenalidomide in treating mantle cell lymphoma. PURPOSE: This randomized phase II trial studies rituximab, bortezomib, bendamustine, and lenalidomide in treating previously untreated older patients with mantle cell lymphoma.
Key facts
- Study ID
- NCT01415752
- Run by
- Eastern Cooperative Oncology Group
- People needed
- 373
- Starts
- 2012-08-09
- Expected to finish
- 2031-09-01
- Last updated by the study team
- 2026-06-03
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Alaska Women's Cancer Care — Anchorage, Alaska, United States
- Anchorage Oncology Centre — Anchorage, Alaska, United States
- Katmai Oncology Group — Anchorage, Alaska, United States
- Providence Alaska Medical Center — Anchorage, Alaska, United States
- Kaiser Permanente-Deer Valley Medical Center — Antioch, California, United States
- Kaiser Permanente, Fremont — Fremont, California, United States
- Kaiser Permanente — Fresno, California, United States
- Los Angeles County-USC Medical Center — Los Angeles, California, United States
- USC / Norris Comprehensive Cancer Center — Los Angeles, California, United States
- Kaiser Permanente-Modesto — Modesto, California, United States
- Kaiser Permanente-Oakland — Oakland, California, United States
- Kaiser Permanente-Redwood City — Redwood City, California, United States
- Kaiser Permanente-Richmond — Richmond, California, United States
- Kaiser Permanente-Roseville — Roseville, California, United States
- Kaiser Permanente-South Sacramento — Sacramento, California, United States
- Kaiser Permanente - Sacramento — Sacramento, California, United States
- Kaiser Permanente-San Francisco — San Francisco, California, United States
- Kaiser Permanente-Santa Teresa-San Jose — San Jose, California, United States
- Kaiser Permanente San Leandro — San Leandro, California, United States
- Kaiser Permanente-San Rafael — San Rafael, California, United States
- Kaiser Permanente Medical Center - Santa Clara — Santa Clara, California, United States
- Kaiser Permanente-Santa Rosa — Santa Rosa, California, United States
- Kaiser Permanente-South San Francisco — South San Francisco, California, United States
- Stanford University Hospitals and Clinics — Stanford, California, United States
- Alaska Breast Care and Surgery LLC — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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