Expression of Angiogenic Factors in Myocardial Tissue

Completed

Conditions studied: Coronary Artery Disease

In brief

The purpose of this study is to evaluate whether angiogenesis is decreased in diabetic patients with coronary artery disease compared to non-diabetics with coronary artery disease. The protein expression of angiogenic factors will be examined in atrial tissue prior to initiation of cardiopulmonary bypass in patients undergoing coronary bypass surgery. The goal of this project is to evaluate the tissue levels of HIF-1, VEGF and angiostatin in diabetic and non-diabetic patients coming for on-pump coronary artery bypass graft (CABG).

Key facts

Study ID

NCT01414621

Run by

University of Virginia

People needed

60

Starts

2009-08-01

Expected to finish

2011-08-01

Last updated by the study team

2016-03-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• on-pump CABG
• 18 years of age \& older
• informed consent

You may not qualify if…

• active malignancy
• severe lung disease (requiring home O2 therapy)
• severe anemia<8g/dl
• patient with moderate or severe renal dysfunction
• off- pump CABG

Where it is running

• University of Virginia Health System — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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