Ileocecal Sphincter Reflex by Cecal Distension During Colonoscopy
Stopped early
Conditions studied: Irritable Bowel Syndrome
In brief
The aim of the current study is to test the hypothesis that patients with IBS may have a defective ICV pressures and may have small bowel bacterial overgrowth. The goal of the current study is to identify the role and competence of ileocecal valve (ICV) in patients with irritable bowel syndrome. The primary objective is to measure the pressure of the ileocecal valve in patients with and without irritable bowel syndrome (IBS). The Ileocecal valve reflux pressures during air insufflation of cecum will be used.
Key facts
- Study ID
- NCT01413945
- Run by
- Northwell Health
- People needed
- 2
- Starts
- 2013-06-21
- Expected to finish
- 2017-01-18
- Last updated by the study team
- 2019-02-22
Who can join
Age: 20 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients with a history of small bowel bacterial overgrowth or irritable bowel syndrome and who are undergoing routine colonoscopies or subjects who are undergoing routine colonoscopy and test positive for small bowel bacterial overgrowth will be candidates. If the patient has prior lactulose breath test done for clinical purposes then repeat lactulose breath test will not be required. If no prior lactulose breath test has been performed then it will be done as part of this research study. In addition patients who test negative for SBBO will be candidates for the control population.
You may not qualify if…
- Medications-Subjects on any medication that could affect the ileocecal valve high-pressure zone will be excluded; this includes use of prokinetic agents, current use of any antibiotics and anticholinergics. Patients will be excluded if the lactulose breath test is done on antibiotics or during the colonoscopy preparation.
- GI symptoms, conditions and disorders: In addition exclusion criteria will include a history of ileocecal resection or disease affecting the colon and/or small bowel including crohn's disease, ulcerative colitis or diseases causing diarrhea.
Where it is running
- LIJ Medical Center- NSLIJ Health System — New Hyde Park, New York, United States
Full record on ClinicalTrials.gov
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