S1106 Rituximab With Combination Chemotherapy or Bendamustine Hydrochloride Followed by Consolidation Chemotherapy and Stem Cell Transplantation in Older Patients With Previously Untreated Mantle Cell Lymphoma
Completed · Phase 2
Conditions studied: Lymphoma
In brief
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and help kill them or carry cancer-killing substances to them. Others interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy also work in different ways to kill more cancer cells or stop them from growing. It is not yet known whether rituximab is more effective with combination chemotherapy or bendamustine hydrochloride in treating patients with mantle cell lymphoma undergoing peripheral blood stem cell transplantation. PURPOSE: This randomized phase II trial studies how well giving rituximab together with combination chemotherapy or bendamustine hydrochloride followed by consolidation chemotherapy and peripheral blood stem cell transplantation works in treating older patients with previously untreated mantle cell lymphoma.
Key facts
- Study ID
- NCT01412879
- Run by
- SWOG Cancer Research Network
- People needed
- 53
- Starts
- 2011-11-01
- Expected to finish
- 2021-03-01
- Last updated by the study team
- 2021-10-29
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Aurora Presbyterian Hospital — Aurora, Colorado, United States
- Boulder Community Hospital — Boulder, Colorado, United States
- Penrose Cancer Center at Penrose Hospital — Colorado Springs, Colorado, United States
- St. Anthony Central Hospital — Denver, Colorado, United States
- Porter Adventist Hospital — Denver, Colorado, United States
- Presbyterian - St. Luke's Medical Center — Denver, Colorado, United States
- St. Joseph Hospital — Denver, Colorado, United States
- Rose Medical Center — Denver, Colorado, United States
- CCOP - Colorado Cancer Research Program — Denver, Colorado, United States
- Swedish Medical Center — Englewood, Colorado, United States
- North Colorado Medical Center — Greeley, Colorado, United States
- Littleton Adventist Hospital — Littleton, Colorado, United States
- Sky Ridge Medical Center — Lone Tree, Colorado, United States
- Hope Cancer Care Center at Longmont United Hospital — Longmont, Colorado, United States
- McKee Medical Center — Loveland, Colorado, United States
- Parker Adventist Hospital — Parker, Colorado, United States
- St. Mary - Corwin Regional Medical Center — Pueblo, Colorado, United States
- Exempla Lutheran Medical Center — Wheat Ridge, Colorado, United States
- Tunnell Cancer Center at Beebe Medical Center — Lewes, Delaware, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- Florida Hospital Cancer Institute at Florida Hospital Orlando — Orlando, Florida, United States
- St. Joseph Regional Medical Center — Lewiston, Idaho, United States
- Illinois CancerCare - Bloomington — Bloomington, Illinois, United States
- Graham Hospital — Canton, Illinois, United States
- City of Hope Comprehensive Cancer Center — Duarte, California, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.