Exploring Advanced Imaging Techniques to Characterize Botulinum Toxin Diffusion in Human Muscle

Completed · Not applicable · Has a placebo group

Conditions studied: Stroke, Muscle Spasticity

In brief

Since the use of botulinum toxin in treating spasticity has already been proven effective, we are now using magnetic resonance imaging to examine the toxin diffusion within muscle (post injection) in order to determine the specific toxin dose required for an optimal treatment response.

Key facts

Study ID

NCT01412008

Run by

New York Presbyterian Hospital

People needed

5

Starts

2010-03-01

Expected to finish

2012-06-01

Last updated by the study team

2013-10-01

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosis of UMN disease
• clinically significant spasticity in the gastrocnemius muscle to warrant Botox® injection (made at the discretion of Dr. O'Dell)
• naïve to all botulinum toxins in the lower extremity

You may not qualify if…

• MR incompatibility with implanted ferromagnetic devices.[Specifically, they may not participate in this study if they have a pacemaker, an implanted defibrillator or certain other implanted electronic or metallic devices. They will be screened by the MRI staff for past surgical procedures to determine the possibility of having an implanted medical or metallic device, shrapnel, or other metal, such as metal in the eye.]
• Pregnancy or breast feeding

Where it is running

• New York Presbyterian Hospital/Weill Cornell Medical College — New York, New York, United States

Full record on ClinicalTrials.gov

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