Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma
Completed · Phase 2
Conditions studied: Blunt Trauma, Penetrating Wound, Hemorrhagic Shock
In brief
Primary Aim: To determine the feasibility and safety of hypotensive resuscitation for the early treatment of patients with traumatic shock compared to standard fluid resuscitation. Primary Hypotheses: The null hypothesis regarding feasibility is that hypotensive resuscitation will result in the same volume of early crystalloid (normal saline) fluid administration compared to standard crystalloid resuscitation. The null hypothesis regarding safety is that hypotensive resuscitation will result in the same percent of patients surviving to 24 hours after 911 call received at dispatch compared to standard fluid resuscitation. Early resuscitation is defined as all fluid given until 2 hours after arrival in the Emergency Department or until hemorrhage control is achieved in the hospital, whichever occurs earlier.
Key facts
- Study ID
- NCT01411852
- Run by
- University of Washington
- People needed
- 192
- Starts
- 2012-03-01
- Expected to finish
- 2013-04-01
- Last updated by the study team
- 2015-01-13
Who can join
Age: 15 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Alabama Resuscitation Center, University of Alabama — Birmingham, Alabama, United States
- Portland Resuscitation Outcomes Consortium, Oregon Health & Sciences University — Portland, Oregon, United States
- The Pittsburgh Resuscitation Network, University of Pittsburgh — Pittsburgh, Pennsylvania, United States
- Dallas Center for Resuscitation Research, University of Texas Southwestern Medical Center — Dallas, Texas, United States
- Milwaukee Resuscitation Network, Medical College of Wisconsin — Milwaukee, Wisconsin, United States
- Resuscitation Outcomes Consortium Regional Coordinating Center,University of British Columbia — Vancouver, British Columbia, Canada
Full record on ClinicalTrials.gov
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