Vasoprotective Activities of Low-Fat Milk in Individuals With Metabolic Syndrome

Completed · Not applicable

Conditions studied: Cardiovascular Disease, Metabolic Syndrome, Obesity

In brief

The purpose of this study is to define whether the acute consumption of low-fat milk protects against postprandial vascular endothelial dysfunction by reducing oxidative stress responses that limit nitric oxide bioavailability to the vascular endothelium. The investigators hypothesis is that the consumption of low-fat milk will improve postprandial vascular endothelial function in an oxidative stress-dependent manner that allows greater nitric oxide (NO) bioavailability. The objectives of this study are to 1) examine improvements in postprandial vascular endothelial function in response to low-fat milk ingestion, 2) define low-fat milk-mediated improvements in circulating biomarkers of redox status, and 3) define the mechanism by which low-fat milk improves NO bioavailability. Collectively, the successful completion of these studies is expected to define NO mediated activities of low-fat milk that protect against vascular endothelial dysfunction in individuals at high risk for developing CVD.

Key facts

Study ID

NCT01411293

Run by

University of Connecticut

People needed

21

Starts

2011-08-01

Expected to finish

2013-10-01

Last updated by the study team

2014-01-06

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• specific criteria of the metabolic syndrome (waist circumference (102-137 or 88-123 cm for men and women, respectively), fasting triglycerides 150-300 mg/dL, and fasting glucose (110-180 mg/dL)
• BMI: >30 kg/m2,
• non-dietary supplement users for >2-mo
• no use of any prescription or over-the-counter medications known to affect vasodilatory responses
• no known history of vascular disease
• nonsmokers
• resting blood pressure <140 mmHg
• not taking any medications that control hypertension

You may not qualify if…

• lactose-intolerant
• excessive alcohol consumption (>3 drinks/d or >10 drinks/wk)
• >7 h/wk of aerobic activity
• use of medications known to affect carbohydrate or lipid/lipoprotein metabolism
• regular use of any anti-inflammatory medications (e.g. aspirin, non-steroidal anti-inflammatory drugs) or over-the-counter aids (e.g. fish oils)
• women who are pregnant, lactating, and have initiated or changed birth control in the past 3-mo

Where it is running

• University of Connecticut — Storrs, Connecticut, United States

Full record on ClinicalTrials.gov

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