A Multi-Centered Trial Evaluating the Role of Vitamin D Metabolism in Non-Small Cell Lung Cancer

Stopped early

Conditions studied: Non-Small Cell Lung Cancer

In brief

Vitamin D exerts antiproliferative and differentiating effects in cancers, including non-small cell lung cancer (NSCLC). The active form of Vitamin D is 1,25, dihydroxycholecalciferol (calcitriol) which rapidly induces expression of cytochrome P450 24R-hydroxylase (CYP24A1). CYP24A1 initiates inactivation of calcitriol as a result of successive hydroxylation/oxidation reactions. This study seeks to prospectively determine the relationship between Vitamin D gene expression and median survival as a primary outcome, and between the Vitamin D receptor (VDR)/CYP24A1 gene expression and cancer stage, smoking status, serum 1,25 (OH)2D3 levels as well as CYP24A1 genotype.

Key facts

Study ID

NCT01409681

Run by

University of Michigan Rogel Cancer Center

People needed

41

Starts

2011-05-01

Expected to finish

2013-12-01

Last updated by the study team

2014-03-31

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Scheduled for diagnostic bronchoscopy for suspected advanced stage lung cancer by CT/PET scanning.
• Tumor or lymph node accessible by transbronchial needle aspiration.
• Age 18-80.
• All patients must be informed of the investigational nature of this study and must give written informed consent in accordance with institutional and federal guidelines.

You may not qualify if…

• Unstable cardiovascular disease or other systemic disease
• Mental incompetence/active psychiatric illness
• Medical contraindication for bronchoscopy

Where it is running

• United States Department of Veteran's Affairs Medical Center — Ann Arbor, Michigan, United States
• University of Michigan Cancer Center — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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