Long Term Antihypertensive Exposure and Adverse Metabolic Effects: PEAR Follow-Up Study

Completed · Phase 4

Conditions studied: Drug Induced Hyperglycemia, Secondary Hyperlipidemia

In brief

This is a research study of the long term effects on blood sugar and cholesterol of blood pressure lowering medications. People are invited to participate in this research study if they participated in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR 1, NCT00246519 or PEAR 2, NCT01203852) study and are still taking a thiazide diuretic. In PEAR, the effects on blood pressure, blood sugar, and cholesterol of the high blood pressure drugs hydrochlorothiazide and atenolol over an 18 week period were evaluated. This PEAR follow-up study will determine the effects of thiazide diuretics on blood sugar and cholesterol, but in the period since the PEAR trial. The study hypothesis is that long term exposure to thiazide diuretics results in larger increases in blood sugar and cholesterol levels than short term exposure.

Key facts

Study ID

NCT01409434

Run by

University of Florida

People needed

44

Starts

2010-06-01

Expected to finish

2013-08-01

Last updated by the study team

2014-10-16

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• previously enrolled in PEAR study
• completed last PEAR study visit greater than 6 months prior
• receive thiazide diuretic continuously since PEAR enrollment

You may not qualify if…

• pregnancy

Where it is running

• University of Florida College of Pharmacy — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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