Single Embryo Transfer of a Euploid Embryo Versus Double Embryo Transfer

Completed · Not applicable

Conditions studied: Infertility

In brief

This study seeks to compare the pregnancy and delivery rates of patients who undergo a single embryo transfer, when the embryo has been tested and determined to be chromosomally normal, with pregnancy and delivery rates of patients who undergo a two (2) embryo transfer of untested embryos.

Key facts

Study ID

NCT01408433

Run by

Reproductive Medicine Associates of New Jersey

People needed

175

Starts

2011-08-01

Expected to finish

2014-12-01

Last updated by the study team

2015-03-26

Who can join

Age: 18 and older, up to 43. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Maximum of one (1) prior failed IVF cycle (a failed cycle is any cycle that did not deliver. Pregnancy losses are failed cycles. Ok to participate as a recipient in an egg donor cycle.)
• Female partner less than 43 years old at time of onset of IVF cycle
• Maximum prior day 3 follicle stimulation hormone (FSH) level of 12 (in RMA NJ laboratory)
• Minimum anti-mullerian hormone (AMH)of 1.2 within 1 year
• Normal uterine cavity demonstrated by saline sonogram, hysterosalpingogram or hysteroscopy within 1 year.
• Male partner with greater than 100,000 total motile spermatozoa. Donor sperm ok.
• Body Mass Index (BMI) less than or equal to 30 kg/m2.

You may not qualify if…

• Diagnosis of chronic anovulation (cycles typically longer than 90 days)
• Diagnosis of endometrial insufficiency- prior cycle with endometrial thickness less than 6mm, abnormal endometrial echotexture, persistent endometrial fluid.
• Clinical indication of aneuploidy screening (i.e. history of loss of chromosomally abnormal pregnancies)
• Clinical indication for PGD for single-gene disorder (i.e. PGD is needed to select against the transfer of embryos affected with a specific condition)
• Use of testicular aspiration or biopsy procedures to obtain sperm
• Unevaluated ovarian mass or surgically confirmed stage IV endometriosis
• Presence of hydrosalpinges which communicate with the endometrial cavity
• Any contraindication to undergoing in vitro fertilization

Where it is running

• Reproductive Medicine Associated of New Jersey — Morristown, New Jersey, United States
• Reproductive Medicine Associated of Pennsylvania at lehigh Valley — Allentown, Pennsylvania, United States

Full record on ClinicalTrials.gov

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