Efficacy of Bitter Blockers on Taste Perception in Children and Adults

Completed

Conditions studied: Healthy

In brief

This proposal describes 2 basic research studies that will be conducted sequentially. Study 1 will test the efficacy of both classic and newly developed "generally recognized as a safe" (GRAS) bitter blockers on the perceived bitterness and acceptance of different classes of bitter-tasting compounds by children and compare their responses to adults. Because variations among and between children and adults in terms of sensitivity to different bitter compounds are due in part to genetically determined receptor variation, the investigators will consider genotype when assessing how well bitter blockers perform. In Study 2, the investigators aim to evaluate different methods (forced-choice procedures, hedonic face scales) used for testing children to determine their reliability and reproducibility.

Key facts

Study ID

NCT01407939

Run by

Monell Chemical Senses Center

People needed

215

Starts

2011-04-01

Expected to finish

2016-03-01

Last updated by the study team

2016-03-16

Who can join

Age: 3 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy, term children of either sex and all races/ethnicities will be eligible for this study.
• Children must be between 3 and 10 years of age.

You may not qualify if…

• Children who are on any medications that may alter taste sensitivity
• Mothers who are pregnant

Where it is running

• Monell Chemical Senses Center — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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