PET Imaging of Endotoxin-induced iNOS Activation
Completed · Phase 1
Conditions studied: Pneumonia
In brief
The overall purpose of this research is to gain understanding of the basic responses of the lung to inflammation. Inflammation is the way our bodies react to irritation or injury, and involves red, warm, and often painful swelling of the affected tissue. "Acute lung injury" involves a generalized inflammation to the lung that is activated by any of several conditions: infection, trauma, inhalation of toxic substances, etc. When lung injury is severe, not enough oxygen can get into the body; this can lead to the need for mechanical support of breathing (mechanical ventilation), problems with brain, heart or other organ function, and in some cases, death. Inducible nitric oxide synthase (iNOS) contributes to the development of lung inflammation.
Key facts
- Study ID
- NCT01407796
- Run by
- Washington University School of Medicine
- People needed
- 19
- Starts
- 2010-12-01
- Expected to finish
- 2012-04-01
- Last updated by the study team
- 2014-04-21
Who can join
Age: 19 and older, up to 44. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy man or woman, any race or ethnicity, age 19 - 44 years old
- Screening Pulmonary Function Test
- Screening oxygen saturation by pulse oximetry >97% on room air
- Capable of lying still and supine within the PET/CT scanner for 1.5 hours
- Capable of following instructions for breathing protocol during CT portion of PET/CT
- Able and willing to give informed consent
- BMI < 35
You may not qualify if…
- Pregnancy (confirmed by qualitative serum hCG pregnancy test)
- Lactation
- Active menstruation
- History of cardiopulmonary disease
- Currently taking any prescription medications
- History of tobacco use or illicit drug use within the past year
- Presence of implanted electronic medical device
- Enrollment in another research study of an investigational drug
- Known allergy to both trimethoprim/sulfamethoxazole and amoxicillin
- Known allergy to drugs routinely used during bronchoscopy
- Inability lie flat for 1.5 hours for PET/CT scans or follow breathing protocol instructions for the CT portion of the PET/CT
Where it is running
- Washington University School of Medicne — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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