Comparison Between Epidural and Bilateral Paravertebral Blocks in Liver Resection
Completed · Not applicable
Conditions studied: Liver Disease, Pain
In brief
This prospective, randomized study is intended to assess the efficacy and safety of bilateral continuous paravertebral blocks compared to continuous epidural block for open liver resection. Hypotheses: Bilateral paravertebral blocks are: 1) equally effective in controlling the perioperative pain; and 2) safe, with less frequent complications following open liver resection when compared to continuous epidural block.
Key facts
- Study ID
- NCT01407666
- Run by
- University of Pittsburgh
- People needed
- 100
- Starts
- 2010-08-01
- Expected to finish
- 2014-11-01
- Last updated by the study team
- 2014-12-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- American Society of Anesthesiologists physical status (ASAPS) I to III patients aged over 18 years and scheduled to undergo elective open liver resection at UPMC Presbyterian/Montefiore Hospital will be screened for enrollment in the study. One hundred (100) patients will be enrolled in this study with equal numbers (n = 50) in each arm of the trial. In order to avoid skewed sex difference between the two groups, the sex will be allocated.
You may not qualify if…
- non elective surgery,
- ASAPS IV or greater,
- age younger than 18 years,
- any contraindication to the placement of an epidural catheter or bilateral paravertebral catheters
- chronic pain conditions
- preoperative opioid use
- coagulation abnormalities or patients who are expected to be on therapeutic anticoagulants postoperatively
- allergy to any of the drugs/agents used our study protocol
- preoperative chronic renal dysfunction, who requires renal replacement therapy or serum creatinine greater than 1.4 mg/dL
- altered mental status (not oriented to place, person, or time),
- any comorbid conditions that, in the judgment of the consulting surgeon or anesthesiologist, would proscribe the patient from any aspect of the study, -
- inability to provide adequate informed consent
- refusal to participate in the study.
Where it is running
- University of Pittsburgh School of Medicine — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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