Personal Genomics for Preventive Cardiology

Completed · Not applicable

Conditions studied: Coronary Artery Disease

In brief

The purpose of this study is to see if providing information to a person on their inherited (genetic) risk of cardiovascular disease (CVD) helps to motivate that person to change their diet, lifestyle or medication regimen to alter their risk.

Key facts

Study ID

NCT01406808

Run by

Stanford University

People needed

100

Starts

2011-08-01

Expected to finish

2017-08-01

Last updated by the study team

2017-10-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults age > 18
• Patient seeking cardiovascular risk evaluation
• At intermediate (6-20%) or high risk (> 20%) over 10 years of CAD as defined by Framingham 10 year risk score AND/OR at > 20% risk of CAD over 30 years using the Framingham 30 year risk calculator
• The genetic risk factors have been evaluated predominantly in white/European subjects. However, there is considerable overlap in the genetic architecture of South Asians and Hispanic/Latino populations. Therefore, we will limit our initial studies to these three race/ethnicity groups.

You may not qualify if…

• History of myocardial infarction, angina, stroke, peripheral arterial disease, PCI, or CABG
• Already on lipid lowering therapy
• Anticipated survival <1 year (e.g. metastatic cancer)
• Serious conditions that would limit ability to adhere to recommendations (inability to take statins, exercise)
• Already had genetic testing
• Concurrent enrollment in another clinical trial
• Pregnant or breastfeeding

Where it is running

• Stanford Medical Center — Stanford, California, United States

Full record on ClinicalTrials.gov

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