MRI Study of Tic Remission in Tourette Syndrome

Completed

Conditions studied: Tourette Syndrome

In brief

Doctors provide a ray of hope to children and their parents with the knowledge that, for most patients, symptoms of Tourette syndrome improve by the time they are young adults. The investigators do not know why some improve and others do not. This study is designed to help answer that question. The investigators will use magnetic resonance imaging (MRI) techniques to test whether individuals who experience improvement of their Tourette's (tic remission) have more mature brain connections than those who do not.

Key facts

Study ID

NCT01405859

Run by

University of Utah

People needed

21

Starts

2010-01-01

Expected to finish

2012-06-01

Last updated by the study team

2016-05-12

Who can join

Age: 18 and older, up to 35. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• All subjects: males aged 18-35 with history of Tourette syndrome and at least moderately disabling tics during childhood.
• Persistent Tourette's subjects: history of disabling tics during childhood but no longer taking tic suppressing drugs.
• Tic remission subjects: no longer experiencing any disability (even social discomfort) from tics. Must have had sustained improvement of tics for at least 3 years.
• Normal controls: no longer recruiting.

You may not qualify if…

• Tourette's subjects still taking tic suppressing drugs are excluded. Also excluded are any patients with a condition (such as a pacemaker, recent tattoo, implantable metal device, or claustrophobia) that could make the MRI examination unsafe.

Where it is running

• University of Utah — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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