The Effects of Peanuts and Peanut Products on Glucose Control and Vascular Function

Completed · Phase 1

Conditions studied: Cardiovascular Disease

In brief

Pilot study data have demonstrated that peanuts ameliorate the postprandial glucose and insulin response when incorporated into an acute high fat/high glucose meal. However, it is unclear whether acute consumption of peanuts can also influence vascular function. This study will therefore evaluate the effects of acute peanut consumption on vascular function, glycemic control, and plasma lipids. The hypothesis is that that addition of peanuts to a high fat/high glucose meal will reduce the production of triglycerides, glucose, and improve endothelial function as measured by flow-mediated dilation (FMD).

Key facts

Study ID: NCT01405300
Run by: Penn State University
People needed: 20
Starts: 2011-08-01
Expected to finish: 2014-06-01
Last updated by the study team: 2023-08-21

Who can join

Age: 20 and older, up to 50. Sex: male. Healthy volunteers: accepted.

You may qualify if…

20-50 years of age
LDL-C below 160 mg/dL
Triglyceride below 350 mg/dL
Blood pressure within normal ranges (below 140/90 mmHg)
Not taking medication for elevated lipids, blood pressure or glucose

You may not qualify if…

Allergies to peanuts or dairy products
Known intolerance for high fat meals
History of cardiovascular disease (CVD), kidney disease, diabetes or inflammatory diseases such as GI disorders and arthritis
Use of non-steroidal anti-inflammatories or immunosuppressants
Conditions requiring the use of steroids
Use of medication or supplements for elevated lipids, blood pressure or glucose
Donation of blood or plasma during the study
History of thyroid disease
Women
Lactose intolerance

Where it is running

Penn State University — University Park, Pennsylvania, United States

Full record on ClinicalTrials.gov

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