Non Invasive Positive Pressure Ventilation in Status Asthmaticus

Withdrawn before enrolling · Phase 2

Conditions studied: Status Asthmaticus

In brief

Status Asthmaticus is recognized as a common cause of morbidity in children in the United States (CDC). In recent years, hospitalization rates have reached an all time high. This study will evaluate the effect of early use of noninvasive positive pressure ventilation (NPPV) in children admitted to the pediatric intensive care unit (PICU) with moderate to moderately severe status asthmaticus to test the hypothesis that early initiation of NPPV plus standard of care will result in decreased length of PICU stay, significant improvement in clinical asthma score (CAS) and reduced patient care costs when compared to standard of care alone.

Key facts

Study ID

NCT01403428

Run by

Southern Illinois University

People needed

0

Starts

2011-06-01

Expected to finish

2014-03-01

Last updated by the study team

2014-12-12

Who can join

Age: 1 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1-18 years old
• Known H/O asthma
• With status asthmaticus
• CAS score 2-8 after one dose of systemic steroid, 1 hour of continuous albuterol and 3 doses of ipratropium bromide.

You may not qualify if…

• No previous history of asthma.
• Absence of airway protective reflexes.
• Absence of respiratory drive.
• Problems with clearing oral secretions.
• Need for emergent intubation as determined by the attending physician.
• Facial or airway anomaly or injury precluding the use of tight fitting mask.
• Discretion of the attending physician depending on the severity of illness

Where it is running

• Southern Illinois University School of Medicine — Springfield, Illinois, United States

Full record on ClinicalTrials.gov

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