Cardiac Remote Ischemic Preconditioning Before Elective Major Vascular Surgery
Completed · Phase 1/Phase 2
Conditions studied: Peripheral Arterial Disease
In brief
Vascular surgery is considered a high-risk operation with an anticipated risk of major cardiovascular complications in excess of 5%. The occurrence of a cardiovascular complication after surgery carries a long-term higher mortality risk. The main objective of this investigation is to reduce the proportion of patients having major cardiovascular complications during surgery through a clinical protocol of remote preconditioning that is safe, effective and reproducible.
Key facts
- Study ID
- NCT01403337
- Run by
- Center for Veterans Research and Education
- People needed
- 205
- Starts
- 2011-07-01
- Expected to finish
- 2015-09-01
- Last updated by the study team
- 2016-03-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Eligible patients would be those undergoing elective major vascular surgery at the Minneapolis VA Medical Center for an expanding abdominal aortic aneurysm, obstructive carotid disease, and/or chronic limb ischemia during the study period. All patients must be ≥ 18 years of age and provide written informed consent.
You may not qualify if…
- Exclusion criteria include hypertensive crisis, acute coronary syndrome in the preceding 6 weeks, severe valvular heart disease, peripheral arterial disease of the upper extremities, manifested by a systolic blood pressure difference greater than 20 mmHg, pregnant women, patients unable to understand the consent process due to mental illness, advanced malignancy with limited life expectancy (<1 year), and hemodialysis with a fistula in the upper extremity.
Where it is running
- Minneapolis VA Medical Center — Minneapolis, Minnesota, United States
Full record on ClinicalTrials.gov
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