Prediction of ARrhythmic Events With Positron Emission Tomography

Completed

Conditions studied: Ischemic Cardiomyopathy, Hibernating Myocardium, Nerve; Disorder, Sympathetic

In brief

The hypothesis of PAREPET is that hibernating myocardium (viable myocardium with reduced resting flow) and/or viable but denervated myocardium can predict the risk of sudden death in subjects with ischemic cardiomyopathy.

Key facts

Study ID

NCT01400334

Run by

State University of New York at Buffalo

People needed

257

Starts

2004-07-01

Expected to finish

2012-12-01

Last updated by the study team

2020-10-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• LV EF ≤35% (by nuclear imaging, cardiac catheterization or echocardiography)
• Coronary artery disease documented by cardiac catheterization, a history of definite myocardial infarction, or reversible ischemia on nuclear imaging
• New York State Heart Association functional Class I-III heart failure
• Not a candidate for surgical or percutaneous coronary revascularization at the time of enrollment

You may not qualify if…

• History of resuscitated sudden cardiac death, sustained ventricular tachycardia, appropriate implantable cardiac defibrillator (ICD) discharge, or unexplained syncope
• Myocardial infarction within 30 days
• Coronary artery bypass grafting within 1 year
• Percutaneous intervention within 3 months
• Claustrophobia or physical limitation that would preclude PET scanning
• Pregnancy
• Tricyclic antidepressant drug therapy
• Comorbidities that would be expected to result in noncardiac death within 2 years
• Inability to provide informed consent

Where it is running

• SUNYBuffalo — Buffalo, New York, United States

Full record on ClinicalTrials.gov

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