Cobalamin Absorption From Fortified Food

Completed · Not applicable

Conditions studied: Vitamin B-12 Deficiency, Achlorhydria

In brief

To determine B12 bioavailability from 14C-B12 fortified bread in healthy subjects and in subjects with proton pump inhibitor induced achlorhydria.

Key facts

Study ID

NCT01399164

Run by

USDA, Western Human Nutrition Research Center

People needed

6

Starts

2010-01-01

Expected to finish

2013-09-01

Last updated by the study team

2013-10-22

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• good overall health
• normal absorptive capacity (controls) or with a serum B12 <300 pg/mL and a pepsinogen I level >100 μg/L (ACs).
• All subjects must be available to complete the protocol

You may not qualify if…

• Any chronic health disorder
• Anemia of any kind
• Renal insufficiency
• excessive alcohol consumption
• Prior GI surgery
• Use of OTC or prescription drugs that interfere with B-12 absorption or metabolism
• Use of vitamin supplements
• Pregnancy or lactation

Where it is running

• Western Human Nutrition Center, University of California Davis — Davis, California, United States

Full record on ClinicalTrials.gov

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