Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease (COPD)

Completed · Not applicable

Conditions studied: Pulmonary Disease, Chronic Obstructive

In brief

More patients with chronic obstructive pulmonary disease (COPD) die from cardiovascular disease than direct pulmonary complications. Inflammation and oxidative stress, characteristic in COPD, are likely contributors to the reduction in nitric oxide (NO) bioavailability and vascular endothelial dysfunction in COPD patients; however, this has yet to be determined. Thus, the overall objective of this proposal is to identify the role of NO bioavailability in contributing to vascular endothelial dysfunction in patients with COPD and to provide insight into the molecular mechanisms involved. Our central hypothesis is that inflammation and oxidative stress, both independently, contribute to the reduction in NO bioavailability and vascular endothelial dysfunction in patients with COPD.

Key facts

Study ID

NCT01398943

Run by

Augusta University

People needed

60

Starts

2010-09-01

Expected to finish

2015-06-01

Last updated by the study team

2017-12-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with COPD (GOLD stages II-IV) and matched healthy controls
• Caucasian or African American
• Both men and women
• Current and former smokers

You may not qualify if…

• GOLD Stage I
• Clinical diagnosis of heart disease, hypertension, or metabolic disease
• Vasoactive medications (i.e. nitrates, beta-blockers, ACE inhibitors, Viagra, etc.)
• Pulmonary hypertension
• Hypothyroidism
• Hyper-homocysteinemia
• Interstitial lung disease
• Phenylketonuria
• Pregnancy
• Sleep apnea
• Anemia
• Raynod's phenomenon
• Gangrene of the digits
• History of low platelets or coagulopathies
• Aspirin sensitivity or allergy

Where it is running

• Augusta University — Augusta, Georgia, United States

Full record on ClinicalTrials.gov

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