Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary

Completed

Conditions studied: Chronic Obstructive Pulmonary Disease

In brief

The Multi-Ethnic Study of Atherosclerosis (MESA) - Chronic Obstructive Pulmonary Disease (COPD) Study aims to characterize the pulmonary vascular changes and their biology in early COPD using imaging, gene expression profiling and peripheral cellular measures.

Key facts

Study ID

NCT01397721

Run by

Columbia University

People needed

359

Starts

2009-05-01

Expected to finish

2018-04-30

Last updated by the study team

2024-07-24

Who can join

Age: 50 and older, up to 79. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age 50-79 years at time of enrollment
• ever smokers (10 or more pack-years)
• participation in MESA or EMCAP studies

You may not qualify if…

• clinical cardiovascular disease (left congestive heart failure (CHF), valve disease, coronary artery disease (CAD), stroke, or congenital heart disease),
• asthma, pulmonary embolism or lung disease other than COPD,
• weight > 300 lbs,
• chronic renal insufficiency ([estimated glomerular filtration rate (eGFR)] < 45 mL/min/1.73 m2),
• atrial fibrillation, and
• contraindications to magnetic resonance imagine (MRI), gadolinium, albuterol or spirometry testing.

Where it is running

• UCLA Research Center — Alhambra, California, United States
• Northwestern University Medical School — Chicago, Illinois, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Columbia University — New York, New York, United States

Full record on ClinicalTrials.gov

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