Effects of Avocado When Added to a Meat Patty on Inflammation in Healthy Men

Completed · Not applicable

Conditions studied: Healthy Volunteers

In brief

Avocados are naturally rich in antioxidants, or beneficial compounds, that can help prevent many diseases, like atherosclerosis (hardening of the arteries). When foods that are high in fats are eaten, certain harmful compounds can be absorbed, which can lead to atherosclerosis. One harmful compound is called malondialdehyde, or MDA. This compound can be measured in the blood and the urine after a person eats a high fat meal. Antioxidants found in herbs and spices may lower the absorption of MDA, which could help prevent the development of atherosclerosis. This study will determine whether the beneficial compounds of avocado can reduce absorption of MDA. This will be tested by asking healthy males to eat a high fat ground beef patty with or without avocado and then measuring the amount of MDA in their blood and urine samples. Blood flow will also be measured. Healthy men have been chosen for this study because eating high fat hamburger patties can easily mimic in them the condition that causes atherosclerosis. Avocados are rich in antioxidants, which have been shown in previous studies to reduce the absorption of harmful compounds, like MDA, that are formed during cooking. The results from this study may help to explain how high fat foods can be harmful to the body and how beneficial antioxidants from herbs and spices can protect the body. This will be determined from blood and urine samples after the subjects are given two different meals: a) a plain cooked ground beef patty, and b) or avocado with a cooked ground beef patty.

Key facts

Study ID

NCT01397071

Run by

University of California, Los Angeles

People needed

11

Starts

2011-08-01

Expected to finish

2012-08-01

Last updated by the study team

2019-09-25

Who can join

Age: 18 and older, up to 35. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• 18 - 35 years old males (inclusive)
• Non-smokers
• Must weigh a minimum of 110 pounds
• Willing to maintain normal activity and eating patterns for the duration of the study
• Willing to maintain their normal diet for the duration of the study but avoid dairy, avocado and meat products.

You may not qualify if…

• Females
• Abnormal liver function (aspartate aminotransferase (AST) and alanine aminotransferase (ALT) > 2 x upper limit)
• Currently taking steroidal drugs
• Known HIV positive or AIDS
• Chronic infectious disease
• Cancer treated within the past two years
• Participation in a therapeutic research study within 30 days of baseline
• Consumption of vegetarian diet
• Allergy or sensitivity to dairy products
• Allergic to avocado

Where it is running

• UCLA Center for Human Nutriiton — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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