Effects of Sleep Duration and Architecture on Insulin Sensitivity
Completed · Not applicable
Conditions studied: Insulin Resistance
In brief
This pilot clinical trial will test the hypotheses that sleep restriction (for 5 nights), in comparison to "normal sleep", will: 1. Decrease peripheral insulin sensitivity and glucose tolerance, as measured by the hyperinsulinemic-euglycemic clamp and oral glucose tolerance test. 2. Decrease hepatic insulin sensitivity, as assessed by stable isotope studies of endogenous glucose production, gluconeogenesis and glycogenolysis.
Key facts
- Study ID
- NCT01396941
- Run by
- University of California, San Francisco
- People needed
- 10
- Starts
- 2011-05-01
- Expected to finish
- 2014-12-01
- Last updated by the study team
- 2021-07-19
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18-45 years
- Regular work hours (ie, no night-time or shift work within the past 6 months)
- Pittsburgh Sleep Quality Index (PSQI) Score <5
- Average nightly sleep duration 6-9 hours (per screening actigraphy)
You may not qualify if…
- Current or prior diabetes, gestational diabetes, impaired glucose tolerance or impaired fasting glucose
- Type 2 diabetes in biological parents
- BMI >=25
- Pregnancy
- Chronic medical condition, including: psychiatric disorders, heart disease, pulmonary disease, infectious diseases, rheumatological and neurological disorders
- Use of prescribed medications on a regular basis.
- History of disorder involving hypothalamic, pituitary or adrenal glands
- History of or current sleep disorders (insomnia, restless leg syndrome, sleep disordered breathing, narcolepsy, etc)
- Anemia
- Cognitive impairment
Where it is running
- UCSF San Francisco General Hospital — San Francisco, California, United States
Full record on ClinicalTrials.gov
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