Effects of Dronabinol (Oral THC) on Cannabis Use

Completed · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Marijuana Smoking

In brief

Study participants received dronabinol (0, 120mg/day and 240mg/day) for 12 consecutive days in a randomized order. During each dronabinol maintenance period they were able to self-administer active or placebo cannabis using either a progressive ratio schedule or choice between cannabis and monetary alternative.

Key facts

Study ID

NCT01394185

Run by

Johns Hopkins University

People needed

25

Starts

2011-02-01

Expected to finish

2012-09-01

Last updated by the study team

2017-08-03

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Current use of marijuana
• Able to give informed consent

You may not qualify if…

• Daily use of psychoactive medication
• Current Axis I psychiatric disorder other than dependence on cannabis or nicotine, or abuse of drugs or alcohol
• Women who are pregnant, breast feeding, or planning to become pregnant within the next 3 months
• Those seeking treatment for cannabis-related problems or using cannabis under the guidance of a physician for a medical disorder
• Uncontrolled or unstable cardiovascular disease
• Allergy to sesame oil

Where it is running

• Johns Hopkins University (Bayview Campus) — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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