Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar Depression

Completed · Not applicable

Conditions studied: Bipolar Depression

In brief

The investigators propose to study and compare measures of brain energy metabolism in geriatric bipolar individuals and healthy older adults. The investigators would also like to investigate changes in brain energy metabolites associated with CoQ10 administration in older bipolar individuals. Finally, resting state functional Magnetic Resonance Imaging (fMRI) will be conducted in order to explore frontal and limbic circuitry in geriatric bipolar disorder. * Primary Hypothesis: Baseline beta NTP and NAA will be lower, and PCr and lactate higher in Geri BPD compared with older healthy controls * Secondary Hypothesis: Changes in PCr and beta NTP will be demonstrated in Geri BD group challenged with CoQ 10.

Key facts

Study ID
NCT01390389
Run by
Mclean Hospital
People needed
19
Starts
2011-07-01
Expected to finish
2012-07-01
Last updated by the study team
2017-12-07

Who can join

Age: 55 and older, up to 89. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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