Polycystic Ovary Syndrome Genetics and Treatment Response

Status unconfirmed · Not applicable

Conditions studied: Polycystic Ovary Syndrome

In brief

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women. Women with PCOS have a high risk of prediabetes, type 2 diabetes and heart disease. The investigators have found a possible change in the DNA (genes of the body that encode all of our traits) that seems to be related to insulin resistance. In this study, the investigators will try to determine whether the change in the gene affects a woman's ability to respond to a common treatment for PCOS, metformin. These studies will uncover the change in a gene that might be one of the causes of PCOS. Discovering this gene will help better understand the diabetes and insulin abnormalities that are common in PCOS and will help us to better diagnose and treat PCOS to prevent the diabetes in these women.

Key facts

Study ID

NCT01389778

Run by

Massachusetts General Hospital

People needed

200

Starts

2011-06-01

Expected to finish

2019-10-01

Last updated by the study team

2018-08-16

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Polycystic ovary syndrome
• No medications for 1 month
• Good general health

You may not qualify if…

• Smoker
• Acute infection or chronic disease
• Diabetes
• Trying to get pregnant
• Bleeding disorders

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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