Effect of Gender and HIV Infection on Zidovudine and Lamivudine Pharmacokinetics

Completed · Phase 4

Conditions studied: HIV

In brief

This study evaluated the blood and blood cell concentrations of zidovudine and lamivudine in men versus women and in those with versus without HIV infection. Additionally, markers of side effects were correlated with blood levels of the drugs. The hypothesis was that women and those with HIV would have higher drug levels, as well as markers of side effects.

Key facts

Study ID

NCT01386970

Run by

University of Colorado, Denver

People needed

43

Starts

2005-05-01

Expected to finish

2010-07-01

Last updated by the study team

2020-03-16

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Documented physician-diagnosed HIV-infection (HIV+ antibody or plasma HIV-RNA+); HIV-negative volunteers must have a negative HIV-ELISA.
• Age 18 to 55 years;
• Either antiretroviral naïve, or no HIV-therapy in the preceding 6 months;
• Planned antiretroviral regimen includes standard doses of ZDV plus 3TC as part of the antiretroviral regimen. Once- or twice-daily 3TC will be allowed.

You may not qualify if…

• Any medical condition that in the opinion of the investigators would jeopardize the intent of the study.
• In the opinion of the investigator, any concomitant immunomodulatory medications, chemotherapeutic agents, investigational drugs, and alternative therapies, including, glucocorticoids, recombinant growth factors or cytokines (e.g. Granulocyte-macrophage colony-stimulating factor, Granulocyte colony-stimulating factor, interferon-alpha or gamma, human growth hormone, etc), ribavirin, birth-control pills, and sex hormones that could interfere with the cellular pharmacology of the study medications;
• Concomitant medications that interfere with renal drug clearances including, tenofovir, adefovir, cidofovir, ganciclovir, probenecid, or any similarly problematic medication in the opinion of the investigators;
• Concomitant warfarin or daily aspirin (to prevent excess bleeding from biopsy).
• Pregnancy or a plan to become pregnant, or menopause;
• Any > or = grade II abnormality in hemoglobin, absolute neutrophil count, routine liver function tests, serum creatinine, or other organ function abnormalities.
• Any medical or personal condition that, in the judgment of the investigators, may influence the subject's ability to comply with study conditions, such as active mental illnesses, or plans to leave the geographical area.
• Inability to give informed consent.
• Triple nucleoside analog reverse transcriptase regimens.

Where it is running

• University of Colorado Denver and Health Sciences Center — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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