The Efficacy of Diclofenac Gel for Breakthrough Pain and the Neuropathic Components of Pain in Knee Osteoarthritis

Completed · Phase 4

Conditions studied: Knee Osteoarthritis

In brief

The purpose of this proposed study is to conduct a trial with knee osteoarthritis (OA) patients using the diclofenac gel.

Key facts

Study ID

NCT01383954

Run by

Brigham and Women's Hospital

People needed

52

Starts

2011-06-01

Expected to finish

2012-12-01

Last updated by the study team

2017-08-15

Who can join

Age: 20 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 20-75
• Unilateral or bilateral knee osteoarthritis (OA), confirmed radiographically.
• Patients taking oral non-steroidal anti-inflammatory drugs (NSAIDs) in the amount and schedule prior to the breakthrough period will be permitted.

You may not qualify if…

• Patients with clinical history of anterior cruciate ligament (ACL) involvement.
• Patients on tricyclic antidepressants or anticonvulsants (neuropathic medications)
• History of ulcers or gastrointestinal (GI) bleeding
• Coagulation disorders
• Hypersensitivity to Aspirin or NSAIDS
• Congestive Heart Failure and Edema
• Advanced renal disease
• Aspirin triad
• Pregnant women

Where it is running

• Brigham and Women's Hospital — Chestnut Hill, Massachusetts, United States

Full record on ClinicalTrials.gov

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