Remote Ischemic PreConditioning Effect on Postsurgical Pain

Completed · Not applicable · Has a placebo group

Conditions studied: Pain

In brief

Remote Ischemic PreConditioning (RIPC) will improve the postoperative pain experience in patients undergoing abdominal surgery. Although abdominal surgery can be a lifesaving procedure many people have a significant amount of postsurgical pain. Severe postsurgical pain may lead to chronic pain in some people. "Remote Ischemic Preconditioning" may reduce the amount of postsurgical pain. Remote ischemic preconditioning is done by inflating a balloon (very similar to a blood pressure cuff) on the leg until it blocks blood flow for a few minutes. The cuff is then deflated and blood flow resumes. The process is repeated up to three times. This procedure causes the body to increase its natural pain relief system that may help to decrease the amount of postsurgical pain.

Key facts

Study ID

NCT01383317

Run by

Wake Forest University Health Sciences

People needed

64

Starts

2011-06-01

Expected to finish

2017-04-30

Last updated by the study team

2018-09-05

Who can join

Age: 30 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 30-80
• Undergoing elective open intra-peritoneal surgery
• Able to provide written informed consent to participate
• Laparoscopic abdominal surgery

You may not qualify if…

• Ongoing Workman's Compensation claim
• >50mg/day of oral morphine or morphine equivalent
• Currently being treated for lower extremity DVT
• Known intracranial hypertension (not excluding patients with a functioning VP shunt)
• Known Hypercoagulable state (e.g. factor V Leiden, protein s or c deficiency)
• Ongoing localized thigh pain
• Planned epidural analgesia
• Pregnancy
• Any DSM IV-R Axis I psychotic disorders
• Unable to understand English
• Unable to understand the consent form

Where it is running

• Wake Forest University Baptist Medical Center — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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