Determination of the Pathophysicologic Collagen Changes in the Diabetic Achilles Tendon

Completed

Conditions studied: Diabetic Foot Ulcers, Equinus Deformity

In brief

This is a pilot study examining tendon collagen, collagen cross-linking, and markers of tendon extracellular matrix metabolism in the Achilles tendon of diabetic patients with ulcerations and amputations of the lower extremity.

Key facts

Study ID

NCT01382628

Run by

Georgetown University

People needed

10

Starts

2011-05-01

Expected to finish

2019-04-01

Last updated by the study team

2019-08-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Type I or Type II Diabetes - diagnosed by their primary care provider
• Demonstrates an equinus ankle deformity - Less than 0 degrees of passive dorsiflexion at the ankle joint with the knee extended or flexed.
• Preulcerative plantar foot lesions - In the form of a callus with the epithelium intact
• OR may also have the following:
• Plantar ulceration without a history of amputations
• Plantar ulceration with a history of digital amputations - or planned digital amputation
• Plantar ulceration with a history of transmetatarsal amputations - or planned transmetatarsal amputation
• Plantar ulceration with a history of Chopart's or more proximal amputation - or planned Chopart's or more proximal amputation

You may not qualify if…

• Does not demonstrate an equinus ankle deformity
• Cannot undergo elective surgery for any reason
• History of Achilles tendon lengthening procedure performed
• History of traumatic (acute or chronic) injury to the Achilles tendon

Where it is running

• Georgetown University Hospital Center for Wound Healing — Washington D.C., District of Columbia, United States

Full record on ClinicalTrials.gov

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