Prevalence of Decreased Corneal Sensation in Patients With Chronic Inflammatory Demyelinating Polyneuropathy
Completed
Conditions studied: Chronic Inflammatory Demyelinating Polyneuropathy
In brief
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a demyelinating chronic progressive or relapsing neuropathy believed to be secondary to an autoimmune response against peripheral nerve antigens.5 We have observed two patients with CIDP with decreased corneal sensation who also suffered neurotrophic corneal ulcers and severe visual loss in the affected eyes. We want to explore the relationship of CIDP and corneal sensitivity. Our hypothesis is that people with CIDP have decreased corneal sensation compared to those without. We plan to perform a prospective study measuring corneal sensation in patients (proposed n=10) with CIDP and without to determine (1) if a difference exists in patients with CIDP compared to controls and (2) the magnitude of the difference. If a difference is detected in corneal sensitivity in patients with CIDP, this awareness amongst physicians and patients may help prevent blinding complications.
Key facts
- Study ID
- NCT01379833
- Run by
- State University of New York at Buffalo
- People needed
- 18
- Starts
- 2011-05-01
- Expected to finish
- 2013-12-01
- Last updated by the study team
- 2019-06-25
Who can join
Age: 18 and older, up to 110. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Participants must be > 18 years of age. Patients with severe CIDP will be enrolled with age-matched controls without CIDP.
You may not qualify if…
- Eye disease (prior or current) other than glasses, Prior eye injury/ trauma, Viral infection (HSV/VZV - prior or current) of eye, Use of contact lenses in last month, Prior eye surgery / laser/lasik, and Use of eye drops other than artificial tears.
Where it is running
- Dent Neurological Institute — Buffalo, New York, United States
Full record on ClinicalTrials.gov
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