Contrast Ultrasound Perfusion Imaging in Peripheral Arterial Disease (PAD)

Completed

Conditions studied: Peripheral Arterial Disease

In brief

Contrast ultrasound is a technique that can quantify blood flow in the tissues of the body by ultrasound detection of microbubble contrast agents that behave in the circulation similar to red blood cells. In this study, the investigators hypothesize that contrast ultrasound of blood flow in the leg (thigh and calf) at rest and during stress produced by medications that mimic exercise (vasodilator stress) can provide information on the location and severity of peripheral vascular disease (blockages of the blood vessels in the leg). The investigators will also determine whether symptom improvement after revascularization (procedures to open up or bypass the blockages) is directly related to the improvement in blood flow.

Key facts

Study ID

NCT01377649

Run by

Oregon Health and Science University

People needed

18

Starts

2011-07-01

Expected to finish

2016-09-01

Last updated by the study team

2016-09-27

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Known or suspected PAD
• Lower extremity angiography or MRA planned or performed within 6 months

You may not qualify if…

• Age <19 y.o.
• Pregnant or lactating females
• Hypersensitivity to ultrasound contrast agent, dipyridamole, or regadenoson
• Severe reactive airways disease
• Evidence right-to-left shunt (identified on screening echo)
• NYHA Class III or IV heart failure.
• Planned amputation
• Unstable coronary artery disease or severe aortic stenosis

Where it is running

• Oregon Health & Science University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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