Measurement of Bispectral Index and Awareness in Patients Undergoing Electrophysiology Studies With Isoproterenol
Completed · Not applicable
Conditions studied: Intraoperative Awareness
In brief
Isoproterenol is used as a cardiac stimulant in electrophysiology studies (EP). Preliminary data suggests that administration of isoproterenol increases the Bispectral index (BIS). BIS is used to monitor neuronal signals under anesthesia. The BIS level is suggested to correspond to the level of consciousness. We hypothesize that isoproterenol increases BIS values because it increases the patient's level of consciousness through its central nervous system (CNS) stimulatory effects. In this study, we will administer increasing doses of isoproterenol to EPS patients. We will measure the BIS levels continuously before and after isoproterenol administration. In addition, we will test the level of awareness of patients by their response to a modified isolated forearm technique.
Key facts
- Study ID
- NCT01377636
- Run by
- NYU Langone Health
- People needed
- 20
- Starts
- 2009-08-01
- Expected to finish
- 2011-10-01
- Last updated by the study team
- 2015-02-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients scheduled for EP studies for catheter ablation of atrial fibrillation under general anesthesia will participate in the study
You may not qualify if…
- Patients with neuromuscular disease precluding the use of succinylcholine will be excluded.
- Patient or cardiologist refusal
Where it is running
- NYU Langone Medical Center, Department of Anesthesiology — New York, New York, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.