Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal Fusion

Stopped early · Not applicable · Has a placebo group

Conditions studied: Spinal Stenosis, Inflammation

In brief

The aim of the proposed study is to examine the effect of DEX on the inflammatory response in major surgery. More importantly, the investigators will correlate changes in the concentration of inflammatory mediators with meaningful clinical outcomes.

Key facts

Study ID

NCT01377623

Run by

NYU Langone Health

People needed

66

Starts

2010-09-01

Expected to finish

2012-01-01

Last updated by the study team

2017-07-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (> 18) male or female who will undergo surgery for spinal fusion with general anesthesia.
• If female, subject is non-lactating and is either:
• Not of childbearing potential
• Of childbearing potential but is not pregnant at time of baseline as determined by pre-surgical pregnancy testing.
• Subject is ASA physical status 1, 2, or 3.

You may not qualify if…

• Cognitively impaired (by history)
• Subject requires chronic antipsychotic history
• Subject is anticipated to require an additional surgery within 90 days after the intended spinal fusion
• Subject known to be in liver failure
• Subject has received treatment with alpha-2-agonist or antagonist within 2 weeks of study entry
• Subject for whom opiates, benzodiazepines, DEX are contraindicated
• Chronic use of steroids/NSAIDs
• Patients with serious bradycardia related arrhythmias, i.e. 2nd degree block.

Where it is running

• NYU Langone Medical Center, Department of Anesthesiology — New York, New York, United States
• Hospital for Special Surgery — New York, New York, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.