OASIS: Osteoarthritis Sensitivity Integration Study

Withdrawn before enrolling · Not applicable

Conditions studied: Osteoarthritis, Chronic Pain

In brief

The primary objective of this study is to evaluate the relative efficacy of a centrally-acting analgesic (duloxetine) versus a peripherally acting analgesic (topical diclofenac) for pain and associated symptom management in knee osteoarthritis. Secondary objectives include the determination of which self-report and experimental pain measures best differentiate those who respond better to duloxetine than diclofenac.

Key facts

Study ID

NCT01377038

Run by

University of Michigan

People needed

0

Starts

2011-09-01

Expected to finish

2015-07-01

Last updated by the study team

2016-10-26

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with knee osteoarthritis as defined by American College of Rheumatology (ACR) criteria
• Males and females age greater than 50 years at time of screening

You may not qualify if…

• History of chronic kidney disease or moderate to severe hepatic impairment
• History of anemia
• Allergy or intolerance of drug intervention
• Inability to participate in outcome measures

Where it is running

• University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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