Assess the Effect of Treating Periodontal Disease on Cardiovascular Function in Young Adults

Completed

Conditions studied: Periodontal Disease, Atherosclerosis

In brief

We propose to examine a population of Native Americans who have had little or no dental care, and to determine if periodontal disease is associated with early signs of vascular dysfunction or systemic inflammation. We then propose to treat the periodontitis and re-evaluate vascular function. We will determine if gingivitis or mild/moderate periodontitis is associated with detectable vascular dysfunction. Microbial metagenomics will be correlated with vascular function.

Key facts

Study ID

NCT01376791

Run by

San Diego State University

People needed

92

Starts

2010-12-01

Expected to finish

2012-12-01

Last updated by the study team

2013-04-23

Who can join

Age: 21 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• American Indian/Alaskan Natives seeking health care at the Indian Health Council, Inc.
• Males and females aged 21-40 years.

You may not qualify if…

• Recent (within 6 months) periodontal treatment
• History of high blood pressure or existing heart disease
• Xerostomia
• Currently receiving treatment for cancer
• Currently taking anti-inflammatory medications (except H2 blockers, statins, or medications that can affect periodontal status
• Immunosuppressed due to medication or HIV infection, or presence of active infection such as hepatitis or tuberculosis
• Fewer than 20 teeth in functional dentition, excluding third molars, or other gross oral pathology

Where it is running

• Indian Health Council — Valley Center, California, United States

Full record on ClinicalTrials.gov

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