Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms

Completed · Phase 3 · Has a placebo group

Conditions studied: Breast Cancer, Gynecologic Cancer

In brief

RATIONALE: Dehydroepiandrosterone (DHEA) may help relieve vaginal symptoms in female cancer survivors. PURPOSE: This randomized phase III trial studies DHEA to see how well it works compared to placebo in treating postmenopausal cancer survivors with vaginal symptoms.

Key facts

Study ID: NCT01376349
Run by: Alliance for Clinical Trials in Oncology
People needed: 464
Starts: 2011-07-01
Expected to finish: 2017-11-01
Last updated by the study team: 2019-02-07

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Age ≥ 18 years
Postmenopausal women with a history of breast or gynecologic cancer (currently no evidence of disease). Note: Postmenopausal status will be determined by the following criteria:
12 months without a period or bilateral oophorectomy or complete chemical ovarian suppression for the past 12 months with continued suppression planned throughout the course of the study
menopausal status will be determined by an FSH and an estradiol value in the postmenopausal range (generally FSH > 40IU/L and estradiol < 10 pg/ml, depending on laboratory) if:
9 months without a period or
post hysterectomy with at least one ovary remaining and less than 55 years old. Note: if age 55 or older with these criteria, then menopausal status does not need to be determined by labs
Significant vaginal complaints. Note: Defined as persistent vaginal dryness and/or pain with intercourse (dyspareunia) of sufficient severity to make a patient desire therapeutic intervention.
Eligibility questionnaire response must be moderate or worse levels of severity on one of the two symptoms, either dryness or dyspareunia. The protocol contains more information.
Vaginal symptoms must have been present ≥ 2 months prior to randomization.
Life expectancy > 12 months.
Ability to complete questionnaires by themselves or with assistance.
Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0 or 1.
The patient must provide informed written consent.
Willing to return to the enrolling institution for follow-up.
Willing to provide blood samples for correlative research purposes.

You may not qualify if…

Initiation or discontinuation of tamoxifen or aromatase inhibitors ≤ 2 months prior to randomization or plans to initiate or discontinue any of these medications during the 12-week study.
Current diagnosis of an active vaginal infection, if symptoms of vaginal infection, this must be ruled out (ie, foul discharge, fever).
Concurrent chemotherapy (long term adjuvant herceptin, lapatanib, and/or bevacizumab is allowed.
Planned use of any vaginal preparations during the study period (including any over the counter or herbal preparations). Note: Water-based lubricants (such as KY jelly) are allowed during sexual intercourse.
Use of any daily non-hormonal vaginal preparations ≤ 1 week prior to study entry.
Exception: Daily water-based lubricants for sexual intercourse. Note: Patients who stop agent may be enrolled after one week.
Current (≤ 4 weeks prior to randomization), or planned during the study period, use of any estrogen product or any kind of hormonal vaginal product including bioidentical hormones, estriol or any androgen product.
Use of pharmacologic soy or phytoestrogen preparations (Dietary intake of soy - ie milk is acceptable).
On a placebo controlled trial for endocrine therapy.
Prior or concurrent pelvic radiation therapy.
Prior radical pelvic surgery, specifically vaginectomy or pelvic exenteration (TAH/BSO) is allowed).
Diagnosis of any of the following conditions within the past five years:
Essential vulvodynia
Vulvar vestibulitis
Bartholin cyst/abscess
History of Bartholin gland surgery
Lichen sclerosis
Lichen planus of the vulvovaginal region
Desquamative vaginitis
History or current diagnosis of any of the following conditions:
Vulvar or vaginal dysplasia
Vaginal prolapse
Women of childbearing potential, premenopausal women.

Where it is running

Aurora Presbyterian Hospital — Aurora, Colorado, United States
Boulder Community Hospital — Boulder, Colorado, United States
Penrose Cancer Center at Penrose Hospital — Colorado Springs, Colorado, United States
St. Anthony Central Hospital — Denver, Colorado, United States
Porter Adventist Hospital — Denver, Colorado, United States
Presbyterian - St. Luke's Medical Center — Denver, Colorado, United States
St. Joseph Hospital — Denver, Colorado, United States
Rose Medical Center — Denver, Colorado, United States
CCOP - Colorado Cancer Research Program — Denver, Colorado, United States
Swedish Medical Center — Englewood, Colorado, United States
Poudre Valley Hospital — Fort Collins, Colorado, United States
Front Range Cancer Specialists — Fort Collins, Colorado, United States
North Colorado Medical Center — Greeley, Colorado, United States
Littleton Adventist Hospital — Littleton, Colorado, United States
Sky Ridge Medical Center — Lone Tree, Colorado, United States
Hope Cancer Care Center at Longmont United Hospital — Longmont, Colorado, United States
McKee Medical Center — Loveland, Colorado, United States
Parker Adventist Hospital — Parker, Colorado, United States
St. Mary - Corwin Regional Medical Center — Pueblo, Colorado, United States
North Suburban Medical Center — Thornton, Colorado, United States
Exempla Lutheran Medical Center — Wheat Ridge, Colorado, United States
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center — Hartford, Connecticut, United States
Herbert D. Kerman Regional Oncology Center - Daytona Beach — Daytona Beach, Florida, United States
University of Florida Shands Cancer Center — Gainesville, Florida, United States
Mayo Clinic Scottsdale — Scottsdale, Arizona, United States

Full record on ClinicalTrials.gov

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