Examination of the Anti-inflammatory and Insulin Sensitizing Properties of Doxycycline in Humans
Completed · Phase 4 · Has a placebo group
Conditions studied: Type 2 Diabetes, Obesity
In brief
Obesity is a heightened state of inflammation in which production of cytokines and matrix metalloproteinases (MMPs) result in loss of function of insulin receptors and insulin resistance. Doxycycline (DOX) is a potent MMP inhibitor. We hypothesize that DOX will enhance insulin sensitivity and decreases inflammation in obese participants with type 2 diabetes (DM2).
Key facts
- Study ID
- NCT01375491
- Run by
- University of California, San Diego
- People needed
- 39
- Starts
- 2009-10-01
- Expected to finish
- 2011-06-01
- Last updated by the study team
- 2020-01-13
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Ambulatory, medically stable, able to give informed consent, and comply with the protocol.
- Obesity with BMI >30 kg/m2.
- DM2 for less than 10 years.
- 7.5% < HA1C < 10%
- Taking insulin and/or oral medications (biguanide, sulfonlylurea, etc.)
You may not qualify if…
- Mental states that would preclude complete understanding of the protocol and compliance.
- Chronic illness such as renal failure (with creatinine clearance <80 ml/min for Specific Aim 2).
- Women of child-bearing age because of the potential hazard to the fetus (doxycycline may cause permanent discoloration of the teeth and deposition in bone inhibiting growth) and because doxycycline may render oral contraceptives less effective.
- Nursing mothers.
- Allergy to tetracyclines.
- Subjects taking the following drugs: penicillin or it's derivatives, anticoagulant therapy, antacids containing aluminum, calcium, or magnesium, iron-containing preparations, bismuth subsalicylate, barbiturates, carbamazepine, phenytoin or methoxyflurane, thiazolidinediones (TZD)
Where it is running
- University of California San Diego Clinical trials Research Institute — La Jolla, California, United States
Full record on ClinicalTrials.gov
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