Stereotactic Radiosurgery or Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases That Have Been Removed By Surgery
Completed · Phase 3
Conditions studied: Cognitive/Functional Effects, Metastatic Cancer, Neurotoxicity, Radiation Toxicity, Unspecified Adult Solid Tumor, Protocol Specific
In brief
RATIONALE: Stereotactic radiosurgery may be able to send x-rays directly to the tumor and cause less damage to normal tissue. Radiation therapy uses high-energy x rays to kill tumor cells. It is not yet known whether stereotactic radiosurgery is more effective than whole-brain radiation therapy in treating patients with brain metastases that have been removed by surgery. PURPOSE: This randomized phase III trial studies how well stereotactic radiosurgery works compared to whole-brain radiation therapy in treating patients with brain metastases that have been removed by surgery.
Key facts
- Study ID
- NCT01372774
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 194
- Starts
- 2011-07-01
- Expected to finish
- 2019-12-15
- Last updated by the study team
- 2022-09-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mills - Peninsula Hospitals — Burlingame, California, United States
- Los Angeles County-USC Medical Center — Los Angeles, California, United States
- USC / Norris Comprehensive Cancer Center — Los Angeles, California, United States
- Christiana Care Health System-Christiana Hospital — Newark, Delaware, United States
- Mount Sinai Medical Center — Miami Beach, Florida, United States
- John B Amos Cancer Center — Columbus, Georgia, United States
- NorthShore University HealthSystem-Evanston Hospital — Evanston, Illinois, United States
- Memorial Hospital of South Bend — South Bend, Indiana, United States
- Lowell General Hospital — Lowell, Massachusetts, United States
- Saint Vincent Hospital/Reliant Medical Group — Worcester, Massachusetts, United States
- West Michigan Cancer Center — Kalamazoo, Michigan, United States
- Sanford Clinic North-Bemidji — Bemidji, Minnesota, United States
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States
- Regions Hospital — Saint Paul, Minnesota, United States
- United Hospital — Saint Paul, Minnesota, United States
- University of Nebraska Medical Center — Omaha, Nebraska, United States
- Wentworth-Douglass Hospital — Dover, New Hampshire, United States
- Somerset Medical Center — Somerville, New Jersey, United States
- State University of New York Upstate Medical University — Syracuse, New York, United States
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
- Novant Health Presbyterian Medical Center — Charlotte, North Carolina, United States
- Sanford Bismarck Medical Center — Bismarck, North Dakota, United States
- Sanford Clinic North-Fargo — Fargo, North Dakota, United States
- Sanford Roger Maris Cancer Center — Fargo, North Dakota, United States
- Summa Akron City Hospital/Cooper Cancer Center — Akron, Ohio, United States
Full record on ClinicalTrials.gov
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