Continuous Chest Compressions vs AHA Standard CPR of 30:2

Completed · Phase 4

Conditions studied: Out of Hospital Cardiac Arrest

In brief

The primary aim of the trial is to compare survival to hospital discharge after continuous chest compressions (CCC) versus standard American Heart Association (AHA) recommended cardiopulmonary resuscitation (CPR) with interrupted chest compressions (ICC) in patients with out-of-hospital cardiac arrest (OOHCA). The primary null hypothesis will be that the rate of survival to hospital discharge is not affected by use of continuous compressions with passive or positive pressure ventilation (intervention group) versus CPR with compressions interrupted for ventilation at a ratio of 30:2 (control group).

Key facts

Study ID

NCT01372748

Run by

University of Washington

People needed

23711

Starts

2011-06-01

Expected to finish

2015-11-01

Last updated by the study team

2016-12-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or more (or local age of consent);
• Initial fire/Emergency Medical Services (EMS) chest compressions provided by Resuscitation Outcomes Consortium (ROC) study participating agency dispatched to the scene;
• Lack of the exclusion criteria below

You may not qualify if…

• EMS witnessed arrest;
• Written do not attempt resuscitation (DNAR) orders;
• Obvious primary asphyxia or respiratory cause of arrest (drowning, strangulation, hanging)
• Advanced airway placed prior to ROC EMS arrival, or pre-existing tracheostomy
• Traumatic cause (blunt, penetrating, burn) of arrest;
• Known prisoners;
• Known pregnancy;
• Uncontrolled bleeding or exsanguination
• Mechanical compression device used during study-assigned compression cycles

Where it is running

• Alabama Resuscitation Center — Birmingham, Alabama, United States
• The Pittsburgh Resuscitation Network, University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• Dallas Center for Resuscitation Research, University of Texas Southwestern Medical Center — Dallas, Texas, United States
• Seattle-King County Center for Resuscitation Research — Seattle, Washington, United States
• Milwaukee Resuscitation Network, Medical College of Wisconsin — Milwaukee, Wisconsin, United States
• University of Ottawa/University of British Columbia Collaborative RCC, Ottawa Health Research — Ottawa, Ontario, Canada
• Rescu — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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