Low-intensity Resistance Exercise and Diet on Arterial Function and Blood Pressure
Completed · Not applicable
Conditions studied: Obesity, Pre-hypertension, Hypertension
In brief
* Obesity is a major risk factor for premature arterial abnormalities including high blood pressure and increased stiffness. Previous studies have shown that weight loss via lifestyle modifications is associated with a decrease in large artery (aorta) stiffness. However, along with decreases in fat mass, hypocaloric diet reduces muscle mass. Low-intensity resistance exercise training (LIRET) results in similar increases in muscle mass and strength than those observed after high-intensity resistance exercise. * The investigators hypothesis is that weight loss via diet combined with LIRET would additively reduce arterial stiffness and blood pressure (BP) in obese women. The investigators also hypothesize that the improved arterial function with weight loss would be associated with beneficial changes in the main mechanisms involved in BP regulation.
Key facts
- Study ID
- NCT01371370
- Run by
- Florida State University
- People needed
- 41
- Starts
- 2010-12-01
- Expected to finish
- 2012-06-01
- Last updated by the study team
- 2014-08-05
Who can join
Age: 40 and older, up to 65. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Female
- 40 to 65 years of age
- Body mass index of 27-39.9
- Sedentary or low active (less than 2 hr per wk)
You may not qualify if…
- Younger than 40 or older than 65 years of age
- Body mass index lower than 27, or 40 or higher
- Physically active or competitively active
- Smoker
- Systolic blood pressure higher than 140 mmHg
- Use of hormone replacement therapy of less than 1 yr
- Use of calcium channel blocker or beta blockers
- Type 1 diabetes
- Uncontrolled type 2 diabetes
Where it is running
- Florida State University — Tallahassee, Florida, United States
Full record on ClinicalTrials.gov
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